Michaela Bartusel, Rizwan Rehimi, Miloš Nikolić, Julia Heggemann, Petros Kolovos, Wilfred F.J. van IJcken, Jade Varineau, Giuliano Crispatzu, Alicia M. Darnell, Elisabeth Mangold, Samantha A. Brugmann, Matthew Vander Heiden, Magdalena Laugsch, Kerstin U. Ludwig, Alvaro Rada-Iglesias, Eliezer Calo. A non-syndromic orofacial cleft risk locus links tRNA splicing defects to neural crest cell pathologies. Preprint.
Jade Varineau, Eliezer Calo. A common cellular response to broad splicing perturbations is characterized by metabolic transcript downregulation driven by the Mdm2–p53 axis. Disease Models and Mechanisms. 2024. Doi.org/10.1242/dmm.050356. MIT Biology News
Fardin Aryan, Diego Detrés, Claire C. Luo, Skylar X. Kim, Arish N. Shah, Michaela Bartusel, Ryan A. Flynn, Eliezer Calo. Nucleolus activity-dependent recruitment and biomolecular condensation by pH sensing. Molecular Cell. 2023. Q&A: Meet the Authors
Usua Oyarbide, Arish N Shah, Morgan Staton, Matthew Snyderman, Adya Sapra, Eliezer Calo, Seth J Corey. SBDS-R126T rescues survival of sbds−/− zebrafish in a dose-dependent manner independently of Tp53. Life Science Alliance. 2023. DOI: 10.26508/lsa.202201856
Jonathan Perr, Andreas Langen, Karim Almahayni, Gianluca Nestola, Peiyuan Chai, Charlotta G. Lebedenko, Regan Volk, Reese M. Caldwell, Malte Spiekermann, Helena Hemberger, Namita Bisaria, Konstantinos Tzelepis, Eliezer Calo, Leonhard Möckl, Balyn Zaro, Ryan A. Flynn. RNA binding proteins and glycoRNAs form domains on the cell surface for cell penetrating peptide entry. 2023. Preprint @ bioRxiv.
Jaberi-Lashkari N, Lee B, Aryan F, Calo E. An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates. Cell Reports. 2023. Preprint @ bioRxiv. Highlighted in Cell Reports and MIT News.
Lee B, Jaberi-Lashkari N, Calo E. A unified view of Low Complexity Regions (LCRs) across species. eLife. 2022. Preprint @ bioRxiv. Highlighted in MIT News.
Taylor AM, Macari ER, Chan IT, Blair MC, Doulatov S, Vo LT, Raiser DM, Siva K, Basak A, Pirouz M, Shah AN, McGrath K, Humphries JM, Stillman E, Alter BP, Calo E, Gregory RI, Sankaran VG, Flygare J, Ebert BL, Zhou Y, Daley GQ, Zon LI. Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 Oct 21;12(566):eabb5831
Oyarbide U, Shah AN, Amaya-Mejia W, Snyderman M, Kell M, Allende D, Calo E, Topczewski J, Corey S. Loss of Sbds in zebrafish leads to neutropenia and pancreas and liver atrophy. JCI Insight. 2020 Aug 6; PMID: 32759502
Shao Z, Flynn RA, Crowe JL, Zhu Y, Liang J, Jiang W, Aryan F, Aoude P, Bertozzi CR, Estes VM, Lee BJ, Bhagat G, Zha S, Calo E. DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. Nature. 2020;579(7798):291–296. PMID: 32103174. Highlighted in Nature and MIT Biology News Brief.
Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Custo Greig E, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E, Zon LI. RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol. 2020;22(4):372–379. PMCID: PMC7185069
Calo E, Gu B, Bowen ME, Aryan F, Zalc A, Liang J, Flynn RA, Swigut T, Chang HY, Attardi LD, Wysocka J. Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature. 2018 Feb 1;554(7690):112–117. PMID: 29364875. Highlighted in MIT News.
Flynn RA, Do BT, Rubin AJ, Calo E, Lee B, Kuchelmeister H, Rale M, Chu C, Kool ET, Wysocka J, Khavari PA, Chang HY. 7SK-BAF axis controls pervasive transcription at enhancers. Nat Struct Mol Biol. 2016 Mar;23(3):231–238. PMCID: PMC4982704
Calo E, Flynn RA, Martin L, Spitale RC, Chang HY, Wysocka J. RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Nature. 2015 Feb 12;518(7538):249–253. PMCID: PMC4827702
Buecker C, Srinivasan R, Wu Z, Calo E, Acampora D, Faial T, Simeone A, Tan M, Swigut T, Wysocka J. Reorganization of enhancer patterns in transition from naive to primed pluripotency. Cell Stem Cell. 2014 Jun 5;14(6):838–853. PMCID: PMC4491504
Calo E, Wysocka J. Modification of enhancer chromatin: what, how, and why? Mol Cell. 2013 Mar 7;49(5):825–837. PMCID: PMC3857148
Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA. The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes Dev. 2013 May 1;27(9):1003–1015. PMCID: PMC3656319
Pritchard CD, O’Shea TM, Siegwart DJ, Calo E, Anderson DG, Reynolds FM, Thomas JA, Slotkin JR, Woodard EJ, Langer R. An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate. Biomaterials. 2011 Jan;32(2):587–597. PMCID: PMC4070531
Calo E, Quintero-Estades JA, Danielian PS, Nedelcu S, Berman SD, Lees JA. Rb regulates fate choice and lineage commitment in vivo. Nature. 2010 Aug 26;466(7310):1110–1114. PMCID: PMC2933655
Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, Haigis K, Gulino A, Lees JA. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell. 2009 Mar 3;15(3):184–194. PMCID: PMC2880703
Berman SD, Calo E, Landman AS, Danielian PS, Miller ES, West JC, Fonhoue BD, Caron A, Bronson R, Bouxsein ML, Mukherjee S, Lees JA. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11851–11856. PMCID: PMC2575280